Publication Details

FireProt: web server for automated design of thermostable proteins

MUSIL Miloš, MARTÍNEK Tomáš and ZENDULKA Jaroslav. FireProt: web server for automated design of thermostable proteins. In: DAZ & WIKT 2018 Proceedings. Brno, 2018, pp. 1-4.
Type
conference paper
Language
english
Authors
Musil Miloš, Ing., Ph.D. (DIFS FIT BUT)
Martínek Tomáš, doc. Ing., Ph.D. (DCSY FIT BUT)
Zendulka Jaroslav, doc. Ing., CSc. (DIFS FIT BUT)
Annotation

There is a continuous interest in increasing proteins stability to enhance their usability in numerous biomedical and biotechnological applications. Only a single-point mutations with a small impact on protein stability are typically predicted with the existing tools, while more complex multiple-point mutants are necessary for useful stabilization. Here, we present FireProt, a web server for automated design of multiplepoint thermostable mutants that combines structural and evolutionary information in its calculation core. The server is complemented with interactive, easy-to-use interface that allows users to directly analyze and optionally modify designed thermostable mutants.

Published
2018
Pages
1-4
Proceedings
DAZ & WIKT 2018 Proceedings
Conference
Data a znalosti 2018, Brno, CZ
Place
Brno, CZ
BibTeX 
@INPROCEEDINGS{FITPUB11818,
   author = "Milo\v{s} Musil and Tom\'{a}\v{s} Mart\'{i}nek and Jaroslav Zendulka",
   title = "FireProt: web server for automated design of thermostable proteins",
   pages = "1--4",
   booktitle = "DAZ \& WIKT 2018 Proceedings",
   year = 2018,
   location = "Brno, CZ",
   language = "english",
   url = "https://www.fit.vut.cz/research/publication/11818"
}
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