Publication Details

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

CHYRÁ Zuzana, ŠEVČÍKOVÁ Tereza, VOJTA Petr, PUTEROVÁ Janka, BROŽOVÁ Lucie, GROWKOVÁ Kateřina, FILIPOVÁ Jana, ZÁTOPKOVÁ Martina, GROSICKI Sebastian, BARCHANICKA Agnieszka, JĘDRZEJCZAK Wiesław W., WASZCZUK-GAJDA Anna, JUNGOVÁ Alexandra, MIKULÁŠOVÁ Aneta, HAJDÚCH Marián, MOKREJŠ Martin, POUR Luděk, ŠTORK Martin, HARVANOVÁ Ľubica, MISTRÍK Martin, MIKALA Gábor, ROBAK Paweł, CZYŻ Anna, DĘBSKI Jakub, USNARSKA-ZUBKIEWICZ Lidia, JURCZYSZYN Artur, STEJSKAL Lukáš, MORGAN Gareth, KRYUKOV Fedor, BUDINSKÁ Eva, ŠIMÍČEK Michal, JELÍNEK Tomáš, HRDINKA Matouš and HÁJEK Roman. Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis. Haematologica, vol. 106, no. 2, 2021, pp. 601-604. ISSN 1592-8721. Available from: https://haematologica.org/article/view/9744
Czech title
Heterogenní mutační spektrum a deregulované buněčné dráhy v aberantních plazmatických buňkách podtrhují molekulární patologii primární amyloidózy
Type
journal article
Language
english
Authors
Chyrá Zuzana (LF OU)
Ševčíková Tereza (LF OU)
Vojta Petr (LF OU)
Puterová Janka, Ing., Ph.D. (DIFS FIT BUT)
Brožová Lucie (LF MUNI)
Growková Kateřina (LF OU)
Filipová Jana (LF OU)
Zátopková Martina (LF OU)
Grosicki Sebastian (SUM)
Barchanicka Agnieszka (SUM)
Jędrzejczak Wiesław W. (WUM)
Waszczuk-Gajda Anna (WUM)
Jungová Alexandra (LFP)
Mikulášová Aneta (NCU)
Hajdúch Marián (LF UPOL)
Mokrejš Martin (VŠB-TUO)
Pour Luděk (FN Brno)
Štork Martin (FN Brno)
Harvanová Ľubica (LF UNIBA)
Mistrík Martin (LF UNIBA)
Mikala Gábor (SPHC)
Robak Paweł (UML)
Czyż Anna (WUM)
Dębski Jakub (WUM)
Usnarska-Zubkiewicz Lidia (WUM)
Jurczyszyn Artur (UJ-CM)
Stejskal Lukáš (SNOP)
Morgan Gareth (MED-NYU)
Kryukov Fedor (FNO)
Budinská Eva, Mgr., Ph.D. (SCI MUNI)
Šimíček Michal (FNO)
Jelínek Tomáš (FNO)
Hrdinka Matouš (FNO)
Hájek Roman (FNO)
URL
Keywords

amyloidosis, multiple myeloma, clonality, cancer

Abstract

We aim to provide the very first insight into ALA (amyloidosis) +MM (multiple myeloma) molecular profiles and compare the results with ALA and with MM. Our detailed study of ALA and ALA+MM represents an important step towards the improved understanding of their genetic and transcriptomic background, which is a
prerequisite for the development of optimal treatment strategies in the future.

Published
2021
Pages
601-604
Journal
Haematologica, vol. 106, no. 2, ISSN 1592-8721
Publisher
Ferrata Storti Foundation
DOI
10.3324/haematol.2019.239756
UT WoS
000615767000010
EID Scopus
2-s2.0-85100634389
BibTeX 
@ARTICLE{FITPUB12227,
   author = "Zuzana Chyr\'{a} and Tereza \v{S}ev\v{c}\'{i}kov\'{a} and Petr Vojta and Janka Puterov\'{a} and Lucie Bro\v{z}ov\'{a} and Kate\v{r}ina Growkov\'{a} and Jana Filipov\'{a} and Martina Z\'{a}topkov\'{a} and Sebastian Grosicki and Agnieszka Barchanicka and W. Wies\law J\k{e}drzejczak and Anna Waszczuk-Gajda and Alexandra Jungov\'{a} and Aneta Mikul\'{a}\v{s}ov\'{a} and Mari\'{a}n Hajd\'{u}ch and Martin Mokrej\v{s} and Lud\v{e}k Pour and Martin \v{S}tork and \'{L}ubica Harvanov\'{a} and Martin Mistr\'{i}k and G\'{a}bor Mikala and Pawe\l Robak and Anna Czy\'{z} and Jakub D\k{e}bski and Lidia Usnarska-Zubkiewicz and Artur Jurczyszyn and Luk\'{a}\v{s} Stejskal and Gareth Morgan and Fedor Kryukov and Eva Budinsk\'{a} and Michal \v{S}im\'{i}\v{c}ek and Tom\'{a}\v{s} Jel\'{i}nek and Matou\v{s} Hrdinka and Roman H\'{a}jek",
   title = "Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis",
   pages = "601--604",
   journal = "Haematologica",
   volume = 106,
   number = 2,
   year = 2021,
   ISSN = "1592-8721",
   doi = "10.3324/haematol.2019.239756",
   language = "english",
   url = "https://www.fit.vut.cz/research/publication/12227"
}
Back to top